It will hasten it, but will not cause it on it's own. The wheel is meant as a biological filtration method - and a good one at that. It houses air loving bacteria of the type that turns ammonia into less toxic waste like nitrite and that into even less toxic waste. The wheel is redundant and only promotes the initial bacteria types. The real shortage is with the final stages of waste export. And that includes, but is not limited to, macro algae, coral uptake (yep, they use waste products too), and non-oxygen loving bacteria (where Matrix comes in). This is also one of the main reasons we do water changes - to get rid of accumulating waste products.
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