you can't treat unless you know what you're dealing with.
most effective treatments are not reef safe, but may be in tank safe depending on the treatment and what livestock you keep.
test the normal params to start trying to figure out where the problem is. salinity, temperature, ph, alkalinity, nitrite, nitrate, ammonia, calcium, etc...
this will at least tell you something or nothing. if there's no physical signs of disease i would suspect water quality next, unless it is an infection in an area where you couldn't observe it e.g. internal/gills.
are the fish eating normally?
my first line of defense when something goes wrong and i don't immediately know what is to do a large water change. as large as i can. then run carbon and polyfilter. it's a shotgun approach, but until you can find the source of the issues, it's the best you're going to get.
do you not use a skimmer?
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Current Tank Info: A rectangular shaped money pit.
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