I only run a skimmer. After a while of dosing you will notice bacteria growing. I first started to see it in high flow areas - inside pumps and hoses. Dont panic the bacteria is harmless, just make sure you have the skimmer running, not only to remove bacteria but to keep your water aerated. Huge colonies of bacteria can deplete oxygen from your reef, so a little surface agitation is good for gas exchange as well. Now that I have a lot of bacterial colonies, I sometimes find a ball of snot. I just use a net and get rid of them. Give it some time.
Cheers! Mark
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2x 65g displays with a 30g cryptic refugium and 30g sump - 55g reef
30g Bio-cube reef - I.M. 30g reef - 45g freshwater
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